Monitor patients for the development of second primary malignancies. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. Smelters may collect this dust and take out the arsenic as a compound called arsenic trioxide as2o3. Arsenic trioxide arsenic trioxide arsenic trioxide hazard class. This trisenox price guide is based on using the discount card which is accepted at most u. Labchem inc 200 william pitt way pittsburgh, pa 15238 company phone number. Arsenic trioxide cas no 27533 material safety data. Identification product name arseniciii oxide cat no.
Arsenic trioxide, arsenous oxide, arsenous acid anhydride. Carefully rinse the material on the bottom of the watchglass, and the sides of the beaker into the sample solution with. Arsenic trioxide is sometimes given in combination with another medicine called tretinoin. Material safety data sheet arsenic iii sulfide, 99. Chemical product and company identification health fire re activity pe rsonal protection o product name. Identification of the substancemixture and of the companyundertaking 1.
Arsenic trioxide material safety data sheet cas no 2753. Search results for arsenic trioxide at sigmaaldrich. Ato was purchased from sigma chemical co st louis, mo, usa and dissolved in naoh alkalinized deionized water in the stock concentration of 1 m and then diluted. Hazard identification very hazardous in case of ingestion. Arsenic trioxide comes as a solution liquid to be injected into a vein by a doctor or nurse in a medical office or clinic. Dailymed trisenox arsenic trioxide injection, solution. It forms readily when elemental metallic arsenic is heated to high temperatures or burned. Arsenic trioxide material safety data sheet integra chemical company 1216 6th ave n kent wa 98032 phone. Arsenic trioxide is the primary form in which arsenic is marketed and consumed.
Wear appropriate protective eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910. Arsenic as icp standard solution 10 gml in dilute hno3 traceable to nist safety data sheet. Arsenic trioxide is sometimes given in combination with another medicine called tretinoin arsenic trioxide. Presumably, when arsenic trioxide is dissolved in water, the solution contains oarsenous acid, h 3 aso 3. The active ingredient of trisenox, arsenic trioxide. Trisenox prices, coupons and patient assistance programs. Arsenic occurs naturally in the environment as an element of the earths crust.
Arsenic trioxide 1 section 1 chemical product and company identification msds name. When as 4 o 6 was dissolved in an acidic aqueous solution, only the undissociated species, asoh 3, was detected. Description of first aid measures firstaid measures after inhalation. Safety data sheet according to federal register vol. Remove victim to fresh air and keep at rest in a position comfortable for breathing. Trisenox arsenic trioxide injection should be administered under the supervision of a physician who is experienced in the management of patients with acute leukemia. Radchem cc po box 166982 brackendowns alberton 1454 telephone.
As an industrial chemical major uses include in the manufacture of wood preservatives. Arsenic trioxide drug bnf content published by nice. The scottish medicines consortium has advised july 2019 that arsenic trioxide trisenox is accepted for use within nhs scotland in combination with alltransretinoic acid atra tretinoin for the induction of remission, and consolidation in adults with newly diagnosed, lowtointermediate risk acute promyelocytic leukaemia characterised by the presence of the t15. The major use of diantimony trioxide ato is as a flame retardant. Method 7901, issue 2, dated 15 august 1994 page 3 of 4 6. Details of the supplier of the safety data sheet emergency telephone number during normal business hours mondayfriday, 8am7pm est, call 800 3430660. Arsenic trioxide has been used as a treatment for leukemia since the late 1800s.
Chemtrec 8004249300 outside usa 7035273887 product identification product name. Arsenic trioxide included in the candidate list of substances of very high concern svhc according to regulation ec no. Arsenic trioxide 27533 material safety data sheet msds. Arsenic trioxide can cause qt interval prolongation and complete atrioventricular block. Wear full protective clothing and nioshapproved selfcontained breathing apparatus with full facepiece operated in the positive. Sodium arsenate and arsenic trioxide are the chemicals i am want to. Arsenic reacts with chromium trioxide with incandescence.
Carefully rinse the material on the bottom of the watchglass, and the sides of the beaker into the sample solution with distilled water. Arsenic trioxide is a strong medication that can cause serious, rarely fatal side effects. In 2003, the worlds largest producer of arsenic compounds was china, followed by chile and peru. Relapsed acute promyelocytic leukemia in a hemodialysis. One patient who became pregnant while receiving arsenic trioxide. Arsenic trioxide is also being studied in the treatment of other types of cancer. Osha, iarc, and ntp do not classify arsenic trioxide. When arsenic trioxide is burned, it releases toxic fumes and arsine gas which is highly toxic. Mineral arsenic trisulfide is a crystalline material while arsenic trisulfide glass is amorphous. Alternate splicing results in multiple transcript variants. Jun 27, 2019 arsenic trioxide was embryolethal and teratogenic in rats when administered on gestation day 9 at a dose approximately 10 times the recommended human daily dose on a mgm. Arsenic trioxide safety data sheet according to federal register vol. Since that time additional studies have been reported examining the efficacy of arsenic trioxide in relapsed acute promyelocytic leukemia apl 25, but little has been published concerning the use of this agent in patients with renal failure. To decrease your risk, your doctor will monitor you closely during treatment.
There has been no domestic production of arsenic since 1985. Safety data sheet arsenic iii oxide noah technologies. In 2003, the united states was the worlds largest consumer of arsenic. This chemical laboratory information profile is not a material safety data sheet. En section 1 identification of the substance mixture and of the company undertaking product identifier product name arsenic trioxide. Arsenic trioxide is a cancer medication that interferes with the growth and spread of cancer cells in the body. A related trivalent arsenic, sodium arsenite, produced teratogenicity when administered during gestation in mice at a dose approximately 5 times the.
Firefighting measures arsenic trioxide is not flammable. Arsenic oxide, arsenic sesquioxide, arsenous oxide, arsenous acid anhydride, arsenous acid company identification. The active ingredient of trisenox, arsenic trioxide, is a human carcinogen. Arsenic iii oxide 4 first aid measures after inhalation. Material safety data sheet hydrofluoric acid, 40% msds section 1. Arsenic trioxide material safety data sheet cas no. Noncombustible solid in bulk form, but a slight explosion hazard in the form of dust when exposed to flame. Arsenic trioxide is usually injected over 1 to 2 hours, but it may be injected over as long as 4 hours if side effects are experienced during the infusion. Arseniciii oxide as2o3 cas no 27533 american chemical. In nature, arsenic is mostly found in minerals and only to a small extent in its elemental form.
Trisenox can cause fetal harm when administered to a pregnant woman. This material does not contain any class 1 ozone depletors. The active ingredient of trisenox, arsenic trioxide, is a human 112 carcinogen. Material safety data sheet arsenic trioxide msds section 1. Chemical product and company identification product name. Arsenic oxide, arsenic iii oxide, arsenious trioxide, arsenious acid anhydride, arsenite, crude arsenic, white arsenic. A mixture of chromium trioxide, and sulfur ignites on warming. Hazardous in case of skin contact irritant, of eye contact irritant, of inhalation. This material contains arsenic trioxide listed as arsenic, inorganic compounds, 100. Before intiating therapy, perform a 12lead ecg, assess serum electrolytes and creatinine, correct preexisting electrolyte. Identification product name arsenic iii oxide cat no. Effects of arsenic trioxide, alltransretinoic acid and.
Arsenic trioxide material safety data sheet cas no 27533. Cdc niosh pocket guide to chemical hazards arsenic. A violent reaction or flaming is likely in the reaction of chromium oxide and aluminum powder. Material safety data sheet arsenic trioxide 4 osha vacated pels. A pseudogene of this gene is found on chromosome 11. Arsenic trioxide is readily absorbed by the digestive system. Carcinogenicity studies have not been conducted with trisenox by 111 intravenous administration. Arsenic trioxide 1 mgml solution for infusion manufacturer. Ato, arsenic trioxide, arsenous acid, diarsenic trioxide. Amorphous forms of materials generally are more inert. Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic promyeloesitik leukemia, or apl. Arsenic trioxide may cause qt prolongation heart muscles take longer to recharge between beats due to an electrical disturbance, which can cause serious or lifethreatening heart rhythm problems. Product name antimony trioxide cas number 9644 formula sb 2 o 3 product cas number % by weight antimony trioxide 9644.
Reacts with sodium or potassium with incandescence. Arsenic trioxide ar aa057 arsenic trioxide lr al057 di arsenic trioxide, arsenous acid, arsenous oxide, white arsenic, arsenic iii oxide, arsenous anhydride chemsupply pty ltd does not warrant that this product is suitable for any use or purpose. When these ores are heated in smelters, most of the arsenic goes up the stack and enters the air as a fine dust. Oct 21, 2014 arsenic trioxide is a white or transparent solid in the form of glassy, shapeless lumps or a crystalline powder that resembles sugar. Arsenic trioxide, arsenious acid ingredients of known acute toxicity. Safety and health topics arsenic occupational safety. Osha considers inorganic arsenic to mean copper acetoarsenite and all inorganic compounds containing arsenic except arsine. Arsenic trioxide, sold under the brand name trisenox among others, is an inorganic compound and medication. The user must ascertain the suitability of the product before use or application intended purpose.
Arsenic trioxide and pentoxide are used to produce. Complete av block has been reported with arsenic trioxide in the 108 published literature including a case of a patient with apl. Elimination is rapid at first halflife of 12 days, by methylation to monomethylarsonic acid and dimethylarsonic acid, and excretion in the urine, but a certain amount 3040% in the case of repeated exposure is incorporated into the bones, muscles, skin. Arsenic is combined with other elements such as oxygen, chlorine, and sulfur to form inorganic arsenic compounds. Arsenic trioxide, the active ingredient, is present at a concentration of 2 mgml. Safety data sheet creation date 22dec2009 revision date 14feb2020 revision number 2 1. Arsenic trioxide 27533 1 mgml by weight 2154814 product. Arsenic trioxide ar aa057 arsenic trioxide lr al057 di arsenic trioxide, arsenous acid, arsenous oxide, white arsenic, arsenic iii oxide, arsenous anhydride chemsupply pty ltd does not. This material does not contain any hazardous air pollutants. However, arsenic is no longer produced in the united states. Can we prepare arsenic stock solution by dissolving.
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